Also, consider getting your pet microchipped before the trip, in case you get separated, and bring that contact information with you.
Taking a road trip with a dog is similar to traveling with kids; they need potty breaks and snacks.
Some dogs are very nervous travelers, so multiple stops help break the trip into shorter, less stressful segments.
Make a plan to ensure you pack all the essentials, make frequent stops, provide plenty of food and water, stay in pet-friendly accommodations, and know the rules and dangers of your destination.