DrAutoimmuneGirl | Donna Mazzola
Balancing Nutrition and Medicine through food and lifestyle
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Pharm D, Functional Medicine, Healing my Hashimotos, Balancing #Nutrition and #Medicine
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A U T O I M M U N I T Y O N T H E R I S E… __ We see an increased incidence of autoimmune disease at a rate of 19% per year __ A huge proponent to this is the gut effect and its relation to immunity __ The microbioime is responsible for producing TGFB and we know TGFB is the primary cytokine for keeping autoimmune disease under control __ So what should we be thinking? 📍Dietary habits - SAD - prevalence and chance of autoimmune disease is elevated 📍Environmental surroundings (we stay in side our vitamin D levels are low) • Lack of exposure to soil bacteria 📍Pollution - more chemical exposure in our atmosphere, in our food supply, diesel exhaust iwhich mpact autoimmune disease __ Our infectious habitat has changed significantly due to hygiene hypothesis __ Food for thought: because we have less infections overall our Th1 response gets bored… if it cant be focused on an infectious disease it starts to focus on self tissue. #autoimmunedisease #autoimmunewarrior #autoimmuneawareness #autoimmune #autoimmunewellness #autoimmunediseases #autoimmunedisorder #autoimmunediseasewarrior #autoimmunelife #autoimmuneillness #hashimotos #hashimotosdisease #rheumatoid #rheumatoidarthritis #lupus #lupuswarrior #psoriasis #multiplesclerosis #ms #celiacdisease #celiac #ibd #crohnsdisease
Ultra-processed foods- such as frozen dinners, sugary cereal, and fast food- account for up to 58% of total daily energy intake in the U.S. according to a new study (doi: https://doi.org/10.1136/bmj-2023-077310) Their findings, a review of 14 articles involving nearly 10 million people: The people who ate more of these foods had a: ✅50% increased risk of cardiovascular disease-related death ✅48-53%percent higher risk of anxiety ✅12% greater risk of Type 2 diabetes. Greater exposure to ultra-processed food was associated with: ✅21% greater risk of death from any cause ✅40% to 66% higher risk of heart disease-related death, obesity, Type 2 diabetes and sleep problems ✅22% increased risk of depression I will continue to preach - all this processed food leads to chronic inflammation and therefore why you see these outcomes. It’s all about reducing inflammation!! Share your thoughts! #inflammation #inflammationdiet #inflammatory
USDA changes policies to school lunch July 1, 2025, the following changes will take place ✅breakfast cereals served at schools will be limited to no more than 6 grams of added sugars per dry ounce ✅yogurt may have no more than 2 grams of added sugars per ounce ✅flavored milk may have no more than 10 grams of added sugars per 8 fluid ounces. (But WHY do we need flavored milk) A second rule, which will take effect on July 1, 2027, requires ✅added sugars be less than 10% of calories across the week in the school lunch and breakfast programs, according to the USDA. According to the CDC, children under the age of 2 should not have any added sugars in their diet. For people age 2 and over, added sugars should constitute less than 10% of their daily calories. If a child consumes 1,600 calories per day, for example, no more than 160 calories of those should come from added sugars. That’s 40 grams of added sugar in a day! How often do you think that is happening now? Just reading labels you know that 160 calories from sugar goes quickly! Share your thoughts….. #addedsugar #sugar #schoollunch #usda #childhoodobesity #obesity #healthymeals #healthylunch
A huge component to this is reducing inflammation and there are several ways to do that through diet and lifestyle- especially stress reduction. _ But there are several measures that have been studied that impact antibodies. _ Lets break it down: 📌GLUTEN FREE DIET: The gluten-free diet may also directly inhibit activity of inflammatory cells. Research has found that the gluten-free diet reduced serum titers of TPOAb and TGAb in euthyroid women with Hashimoto’s thyroiditis. (PMID: 30060266) 📌SELENIUM: A 2016 systematic review and meta-analysis by Wichman et al. showed that Se supplementation effectively reduces serum TPO-Ab levels at 3, 6, and 12 months and serum Tg-Ab at 12 months. Brazil nuts are a great source. 📌ALOE: Aloe vera juice rescues thyroid hormone production by reducing inflammation in the thyroid gland and reducing the need for conversion of T4 into T3. A study that had women take 50mL of Aloe found reduction in TPOAb Baseline: 1,020 to TPOAb 9 Months: 347. (PMID: 29527506) 📌VITAMIN D: A study observed that increased prevalence of Vitamin D deficiency and insufficiency in thyroid peroxidase antibody (TPO-Ab) or thyroglobulin antibody (TgAb) positive patients when compared to those with negative antibody status. A cross-sectional study documented increased the prevalence of TPO-Ab positivity in women with Vitamin D deficiency and insufficiency as compared to Vitamin D sufficient persons. (PMID: 28163731) 📌Turmeric: The active constituent curcumin can suppress NF-kB, the king of inflammatory pathways and considered a key player in altered immune response and chronic inflammation. Personally I put this in my smoothies to reduce overall inflammation! _ Please share your experiences in the comment, let’s get the conversation started on what has worked for you! Check out my vitD and Aloe @besananutrition _ #hashimotosdisease #hashimotos #hashimoto #hashimotosthyroiditis #hashimotoswarrior #hashimotoshealing #hashimotosthyroiditis #hashimotosmom #thyroidhealing #thyroid #thyroidproblems #thyroidhealth #thyroiddisease #thyroidwarrior #thyroidsupport #thyroidissues #thyroidawareness
Estrogen appears to push the immune system in the direction of the proinflammatory Th1 pathways, EXCEPT during pregnancy. Because pregnancy is actually a high-estriol/high-progesterone state, estriol, functionally a weak estrogen and progesterone clearly has anti-estrogen properties - we actually see an improvement because estrogen levels are actually low. This is the potential reason why autoimmune diseases that involve over-expression of Th1 (e.g., rheumatoid arthritis, multiple sclerosis) frequently “go away” during pregnancy but “come back” during postpartum periods. Thus, pregnancy appears to represent a unique situation for the immune system, switching from a Th1-dominant environment to an often Th2-dominant environment. Full Blog post on Drautoimmunegirl.com - Check it out for all the deets! #autoimmunedisease #autoimmuneprotocol #autoimmunepaleo #pregnancylife
I made these every Sunday for over a year and it’s what helped me get past my egg allergy… now I continue to make them every Sunday with my overripe bananas! Recipe: 2 cups oatmeal 60 grams dates 74 grams orgain protein powder (40 grams protein) 2 eggs 5 ounces siggis plant based protein yogurt (vanilla) 2 ripe bananas 1/2 cup almond milk 1 tsp vanilla 1 tsp salt 1 tsp cinnamon 1 tsp baking soda Blend in food processor for 2.5 minutes Put muffin liners in pan scoop 1/4 cup in each and add 4 blueberries to each and mix Bake at 350 for 25 minutes MACROS: 24 g carbs, 5g fat, 9 G protein
Many studies have indicated that alterations in the gut microbiota are important environmental factors in the development of inflammatory and autoimmune diseases.⠀⠀⠀⠀⠀⠀⠀⠀⠀ __⠀⠀⠀⠀⠀⠀⠀⠀⠀ A comparative analysis looked at gut microbiota in Hashimotos patients and healthy controls… WHAT DID THEY FIND?⠀⠀⠀⠀⠀⠀⠀⠀⠀ __⠀⠀⠀⠀⠀⠀⠀⠀⠀ Levels of Fecalibacterium, Bacteroides, Prevotella were decreased. ⠀⠀⠀⠀⠀⠀⠀⠀⠀ __⠀⠀⠀⠀⠀⠀⠀⠀⠀ TRANSLATION: WHAT DO THESE DEFICIENCIES CORRELATE TO???⠀⠀⠀⠀⠀⠀⠀⠀⠀ __⠀⠀⠀⠀⠀⠀⠀⠀⠀ FACALIBACTERIUM: produce butyrate, which is essential for energy metabolism and the normal development of colonic epithelial cells. Other studies have shown that it has an anti-inflammatory effect⠀⠀⠀⠀⠀⠀⠀⠀⠀ __⠀⠀⠀⠀⠀⠀⠀⠀⠀ PREVOTELLA: are also known to produce anti-inflammatory metabolites, ALSO decreased levels have been reported in diseases such as #MultipleSclerosis , #autism, and #T1D⠀⠀⠀⠀⠀⠀⠀⠀⠀ __⠀⠀⠀⠀⠀⠀⠀⠀⠀ BACTEROIDES: ferment fiber into acetates and propionates producing short-chain fatty acids, which are intestinal nutrients that protect the intestinal mucosal barrier and reduce inflammation⠀⠀⠀⠀⠀⠀⠀⠀⠀ __⠀⠀⠀⠀⠀⠀⠀⠀⠀ OVERALL, the changes in gut microbial structure are similar between #IBS and Hashimotos patients⠀⠀⠀⠀⠀⠀⠀⠀⠀ …⠀⠀⠀⠀⠀⠀⠀⠀⠀ These findings are consistent with those of a previous study that reported significant increases in Firmicutes and decreases in Bacteroidetes species in obese, IBS, and MS patient⠀⠀⠀⠀⠀⠀⠀⠀⠀ —⠀⠀⠀⠀⠀⠀⠀⠀⠀ Studies have indicated that microflora of IBS patients has a higher F/B ratio. Therefore, it is thought that an increased F/B ratio corresponds to HT disease status⠀⠀⠀⠀⠀⠀⠀⠀⠀ __⠀⠀⠀⠀⠀⠀⠀⠀⠀ There is just still so much we don’t know about the gut microbiota, but it definitely gives hope! Your gut is everything, especially with autoimmune disorders. This is why I created my PIRH protocol and gut bundle from @besananutrition Share your Thoughts and experience????⠀⠀⠀⠀⠀⠀⠀⠀⠀ …⠀⠀⠀⠀⠀⠀⠀⠀⠀ #hashimotosdisease #hashimotos #hashimoto #hashimotosthyroiditis #hashimotoswarrior #hashimotoshealing #hashimotosthyroiditis #hashimotosmom #thyroidhealing #thyroid #thyroidproblems #thyroidhealth #thyroiddisease #thyroidwarrior #autoimmune #autoimmunedisease #guthealth #leakygut #guthealth
Evidence has accumulated from animal models and human studies to suggest that Th1 cells are involved in the development of organ-specific autoimmune diseases, such as Hashimoto’s, MS, rheumatoid arthritis, and type 1 diabetes. Because pregnancy is actually a high-estriol/high-progesterone state, estriol, functionally a weak estrogen, and progesterone clearly has anti-estrogen properties Although it has been almost universally held that pregnancy is a “high estrogen state,” it is in fact a time when ovarian production of hormones is suppressed and placental production of estrogens, primarily estriol, and progesterone is high. Rheumatoid Arthritis and MS improve during pregnancy as estriol and progesterone may function to inhibit presentation of antigens to Th1 cells, and increases the death (apoptosis) of activated immune cells.
Did you know that estrogen needs to be detoxified in our body through the same phase 1 pathway as drugs, toxins, and various food substances we ingest? The differences in our bodies ability to detoxify in different proportions of 2E, 4E, and 16E have shown to potentially predict risk of different estrogen-related diseases, such as breast cancer. So, you guys should understand detox goes through 2 pathways, phase 1 and phase 2. From what we understand about detoxification in our body, it is important to not only keep our liver healthy so that we can metabolize the excess estrogen initially, but to eat and continue to replenish are necessary cofactors for phase 2 detox with plant based foods!
Important parameters of intermittent fasting on athletic performance include weight loss, maintenance of muscle mass, and post exercise metabolism due to decreases in glycogen stores, low levels of insulin, increase in hormones responsible for lipolysis (fat breakdown), and an increase in free fatty acids (Paoli 2019, Gieske 2018). While intermittent fasting and time restricted eating have gained popularity, it is important for athletes to appreciate how implementing this change in eating impacts metabolic adaptations, body composition, physical performance and overall endurance, and recovery. Additionally, based on the findings one can conclude that while there isn’t a conclusive difference in overall performance in the fasting versus fed state, the fasting state stimulated a higher level of fat oxidation that occurred for 30 minutes post exercise (Rocha da Silva 2018). This is a positive finding, in that we know there isn’t a negative effect as long as exercise performance was maintained at All in all, intermittent fasting in athletes demonstrates a beneficial impact on metabolic parameters and an increase in lipid oxidation, however, does not demonstrate an improvement in athletic performance and recovery.
The activation of the transcription factor of NF-Kappa-Beta has been shown to be inhibited by AKBA (acetyl-11-keto-Beta-boswellic acid), this leads to decreasing cytokines related to inflammation. However, a study was recently done in 2019 assessing the effect of Boswellia Serrata on inflammatory parameters and tumor necrosis factor in a rheumatoid arthritis animal model (Kumar 2019). Utilizing this treatment as an alternative to NSAIDs, anti-inflammatory agents, and immunosuppressive agents may be feasible in early disease management as it has minimal side effects that we would otherwise experience with standard therapy. Kumar R, Singh S, Saksena A, Pal R, Jaiswal R, Kumar R. Effect of Boswellia serrata extract on acute inflammatory parameters and tumor necrosis factor-α in complete Freund’s adjuvant-induced animal model of rheumatoid arthritis.